Diabetes often causes damage to the nerves that connect the legs to the brain, a condition known as peripheral neuropathy. As the nerves become damaged, changes in sensation to the legs may occur. The nerves may stop communicating to the brain, resulting in the complete loss of sensation and a feeling of numbness. Alternatively, the damaged nerves may send incorrect signals to the brain, causing feelings of tingling, burning or pain. These symptoms often begin in the feet and slowly progress up the legs, explains the National Institute of Neurological Disorders and Stroke. You Might Also Like Poor Circulation So why does it happen? That answer's not so simple. Neuropathy as a complication of diabetes is caused by microvascular disease. That's the small vessels that branch of from the main pipeline arteries. The vessels stop carrying blood, which hold oxygen and nutrients, to the nerves and causes them to fail. So how do we correct this? Not easily. If that's the reason, sometimes the individual needs a procedure to restore circulation. Other times, when the main circulation is in good shape, there may be other modalities. One therapy is called MicroVas, which is a non-invasive treatment that stimulates the microvascular circulation to reverse diabetic neuropathy. Select an empirical antibiotic regimen on the basis of the severity of the infection and the likely etiologic agent(s) (B-II). Therapy aimed solely at aerobic gram-positive cocci may be sufficient for mild-to-moderate infections in patients who have not recently received antibiotic therapy (A-II). Broad-spectrum empirical therapy is not routinely required but is indicated for severe infections, pending culture results and antibiotic susceptibility data (B-III). Take into consideration any recent antibiotic therapy and local antibiotic susceptibility data, especially the prevalence of methicillin-resistant S. aureus (MRSA) or other resistant organisms. Definitive therapy should be based on both the culture results and susceptibility data and the clinical response to the empirical regimen (C-III). Of the more than 26 million people in the US with diabetes, about half will develop peripheral neuropathy, a loss of feeling in the lower extremities.(i) This nerve damage means an open sore or injury on the foot may go unnoticed until it becomes infected, which can eventually lead to the need for a partial or full amputation of the foot or lower leg. Diabetes is responsible for more than half of all lower limb amputations performed in the U.S. Each year there are about 88,000 non-injury amputations, and 50 - 75% of them are due to diabetes. In this article and other follow-up articles, I shall highlight the dangers of diabetes if left untreated and the possible consequences that may result. I know because I had first hand experience of it as I had seen both my parents and three of my aunts and an uncle suffered from diabetes as well as myself. I am not sure about others but even though I knew that I am in the high-risk group, I refused to believe until I was diagnosed as diabetic. I had early warning signs but failed to take precautions to avoid it.